NF-κB Signaling Pathways

SnapShot: NF-κB Signaling Pathways

NF-κB, JNK, and TLR Signaling Pathways in Hepatocarcinogenesis

Hepatocellular carcinoma (HCC) is the third largest cause of cancer deaths worldwide. The role of molecular changes in HCC have been used to identify prognostic markers and chemopreventive or therapeutic targets. It seems that toll-like receptors (TLRs) as well as the nuclear factor (NF)-κB, and JNK pathways are critical regulators for the production of the cytokines associated with tumor promo...

NF-κB signaling.

The NF-κB transcription factor is a critical regulator of the immune system, and is responsive to a large number of stimuli. Different stimuli engage signaling pathways to activate NF-κB, and effect distinct cellular responses. Mathematical modeling of the NF-κB network has been useful in studying the dynamic and cross-talk regulation of NF-κB. In this review, we discuss the regulation of NF-κB...

simultaneous analysis of wnt and nf-κb signaling pathways in doxorubicin sensitive and methotrexate resistant plc/ prf/5 cells

background: multi-drug resistance (mdr) is a controversial issue in traditional chemotherapy of aggressive cancers, including hepatocellular carcinoma. the major cause of mdr is suggested to be the aberrant activation of the main signaling pathways such as wnt and nuclear factor kappa-light-chain-enhancer of activated b cells (nf- κb) which have key roles in the maintenance of cancer stem cells...

P133: Targeting NF-Κb Signaling Pathway as Potential Therapeutic with Curcumin in Treatment of Multiple Sclerosis

Curcumin is active component of turmeric and isolated from the rhizome of turmeric, a phenolic natural product. One of inflammatory disease is multiple sclerosis, a multifocal chronic autoimmune inflammatory disease of the CNS, which is also known as a perivascular demyelinating disease. Studies have been shown that neuro-inflammation can have both harmful and beneficial effects on the neuronal...